unc2025 (mertk inhibitor) Search Results


c mer tyrosine kinase mertk inhibitor unc2025  (MedChemExpress)
94
MedChemExpress c mer tyrosine kinase mertk inhibitor unc2025
C Mer Tyrosine Kinase Mertk Inhibitor Unc2025, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/unc2025+(mertk+inhibitor)/UNC2025/pmc12900273-70-99-108
Average 94 stars, based on 1 article reviews
c mer tyrosine kinase mertk inhibitor unc2025 - by Bioz Stars, 2026-10
94/100 stars
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unc2025  (Selleck Chemicals)
93
Selleck Chemicals unc2025
Unc2025, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/unc2025+(mertk+inhibitor)/UNC2025/pmc07360550-265-77-80
Average 93 stars, based on 1 article reviews
unc2025 - by Bioz Stars, 2026-10
93/100 stars
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unc2025 (mertk inhibitor)  (ApexBio)
90
ApexBio unc2025 (mertk inhibitor)
(A, B, C, D, F)HNSCC and TNBC cell lines were treated with vehicle (DMSO), R428, <t>UNC2025,</t> or R428+UNC2025 and relative cell numbers were determined after 72 hours. UM-SCC1, MDAMB231, and NSCLC cell lines were transfected with AXL siRNA (siAXL, siAXL10, siAXL12) or non-targeting siRNA (siNT) and then treated with vehicle or UNC2025 for 72 hours prior to determination of relative cell numbers. (E) NSCLC cell lines were cultured at low density and treated with vehicle (DMSO), R428, UNC2025, or R428+UNC2025 for 10 days. Colonies were stained and counted. *p<0.05, **p<0.01, ***p<0.001, NS=not significant.
Unc2025 (Mertk Inhibitor), supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/unc2025+(mertk+inhibitor)/unc2025+b8016/pmc06215511-108-0-17
Average 90 stars, based on 1 article reviews
unc2025 (mertk inhibitor) - by Bioz Stars, 2026-10
90/100 stars
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anti-mertk (tyr749-753-754) antibody  (Antibodies Inc)
99
Antibodies Inc anti-mertk (tyr749-753-754) antibody
(A, B, C, D, F)HNSCC and TNBC cell lines were treated with vehicle (DMSO), R428, <t>UNC2025,</t> or R428+UNC2025 and relative cell numbers were determined after 72 hours. UM-SCC1, MDAMB231, and NSCLC cell lines were transfected with AXL siRNA (siAXL, siAXL10, siAXL12) or non-targeting siRNA (siNT) and then treated with vehicle or UNC2025 for 72 hours prior to determination of relative cell numbers. (E) NSCLC cell lines were cultured at low density and treated with vehicle (DMSO), R428, UNC2025, or R428+UNC2025 for 10 days. Colonies were stained and counted. *p<0.05, **p<0.01, ***p<0.001, NS=not significant.
Anti Mertk (Tyr749 753 754) Antibody, supplied by Antibodies Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/unc2025+(mertk+inhibitor)/Anti-MerTK+(Tyr749-753-754)+Antibody/antibodies+inc___p186-749
Average 99 stars, based on 1 article reviews
anti-mertk (tyr749-753-754) antibody - by Bioz Stars, 2026-10
99/100 stars
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Image Search Results


(A, B, C, D, F)HNSCC and TNBC cell lines were treated with vehicle (DMSO), R428, UNC2025, or R428+UNC2025 and relative cell numbers were determined after 72 hours. UM-SCC1, MDAMB231, and NSCLC cell lines were transfected with AXL siRNA (siAXL, siAXL10, siAXL12) or non-targeting siRNA (siNT) and then treated with vehicle or UNC2025 for 72 hours prior to determination of relative cell numbers. (E) NSCLC cell lines were cultured at low density and treated with vehicle (DMSO), R428, UNC2025, or R428+UNC2025 for 10 days. Colonies were stained and counted. *p<0.05, **p<0.01, ***p<0.001, NS=not significant.

Journal: Molecular cancer therapeutics

Article Title: MERTK mediates intrinsic and adaptive resistance to AXL-targeting agents

doi: 10.1158/1535-7163.MCT-17-1239

Figure Lengend Snippet: (A, B, C, D, F)HNSCC and TNBC cell lines were treated with vehicle (DMSO), R428, UNC2025, or R428+UNC2025 and relative cell numbers were determined after 72 hours. UM-SCC1, MDAMB231, and NSCLC cell lines were transfected with AXL siRNA (siAXL, siAXL10, siAXL12) or non-targeting siRNA (siNT) and then treated with vehicle or UNC2025 for 72 hours prior to determination of relative cell numbers. (E) NSCLC cell lines were cultured at low density and treated with vehicle (DMSO), R428, UNC2025, or R428+UNC2025 for 10 days. Colonies were stained and counted. *p<0.05, **p<0.01, ***p<0.001, NS=not significant.

Article Snippet: UNC2025 (MERTK inhibitor) was synthesized as previously described ( 26 ) or purchased from Selleck Chemicals or Apexbio.

Techniques: Transfection, Cell Culture, Staining

(A, B)UM-SCC1 and MDAMB231 cells were treated with vehicle (DMSO), R428, UNC2025, or R428+UNC2025 for 24 hours. (C) H1299 cells were transfected with AXL siRNA (siAXL10 or siAXL12) or non-targeting siRNA (siNT) and cells were treated with vehicle or UNC2025 for one hour. Expression of the indicated proteins was assessed in cell lysates by immunoblot. α-Tubulin is shown as a loading control. The data shown are representative of 3 independent experiments.

Journal: Molecular cancer therapeutics

Article Title: MERTK mediates intrinsic and adaptive resistance to AXL-targeting agents

doi: 10.1158/1535-7163.MCT-17-1239

Figure Lengend Snippet: (A, B)UM-SCC1 and MDAMB231 cells were treated with vehicle (DMSO), R428, UNC2025, or R428+UNC2025 for 24 hours. (C) H1299 cells were transfected with AXL siRNA (siAXL10 or siAXL12) or non-targeting siRNA (siNT) and cells were treated with vehicle or UNC2025 for one hour. Expression of the indicated proteins was assessed in cell lysates by immunoblot. α-Tubulin is shown as a loading control. The data shown are representative of 3 independent experiments.

Article Snippet: UNC2025 (MERTK inhibitor) was synthesized as previously described ( 26 ) or purchased from Selleck Chemicals or Apexbio.

Techniques: Transfection, Expressing, Western Blot, Control

Subcutaneous xenografts were generated in nude mice using (A, D) the TNBC MDAMB231 cell line, (B) the HNSCC UW-SCC1 patient-derived xenograft (PDX), or (C) the HNSCC UM-SCC1 cell line. Tumor-bearing mice were treated with vehicle, 25mg/kg R428, 25 mg/kg UNC2025, or R428+UNC2025 administered twice daily via oral gavage. MERTK expression was assessed in tumor cell lysates by immunoblot. α-Tubulin was used as a loading control. (A) MERTK expression was also detected in MDAMB231 tumors using immunohistochemistry. (B, C, D) Tumor volume was measured (n=8 per group). (C, D) pS6rp and Ki67 were detected in tumor sections using IHC. Mean values and standard errors are shown. *p<0.05, **p<0.01, NS=not significant.

Journal: Molecular cancer therapeutics

Article Title: MERTK mediates intrinsic and adaptive resistance to AXL-targeting agents

doi: 10.1158/1535-7163.MCT-17-1239

Figure Lengend Snippet: Subcutaneous xenografts were generated in nude mice using (A, D) the TNBC MDAMB231 cell line, (B) the HNSCC UW-SCC1 patient-derived xenograft (PDX), or (C) the HNSCC UM-SCC1 cell line. Tumor-bearing mice were treated with vehicle, 25mg/kg R428, 25 mg/kg UNC2025, or R428+UNC2025 administered twice daily via oral gavage. MERTK expression was assessed in tumor cell lysates by immunoblot. α-Tubulin was used as a loading control. (A) MERTK expression was also detected in MDAMB231 tumors using immunohistochemistry. (B, C, D) Tumor volume was measured (n=8 per group). (C, D) pS6rp and Ki67 were detected in tumor sections using IHC. Mean values and standard errors are shown. *p<0.05, **p<0.01, NS=not significant.

Article Snippet: UNC2025 (MERTK inhibitor) was synthesized as previously described ( 26 ) or purchased from Selleck Chemicals or Apexbio.

Techniques: Generated, Derivative Assay, Expressing, Western Blot, Control, Immunohistochemistry